CEFOTAXIME SODIUM (CLAFORT)
Clafort contains cefotaxime, belongs to the class of drugs called third generation cephalosporins, off white to pale yellow crystalline powder. It is soluble in water at about 20%, but poorly soluble in common organic solvents including ethanol. It is available in injectable form for IV and IM administration.
Dosage and Administration
Dosage and route of administration should be determined by susceptibility of the causative organisms, severity of the infection, and the condition of the patient. Clafort may be administered IM or IV after reconstitution. The maximum daily dosage should not exceed 12 grams. The following guidelines are used for infections.
Type of Infection Daily Dose(grams) Frequency and Route Gonococcal urethritis/ cervicitis in males and females 0.5 0.5gram IM (single dose) Rectal gonorrhea in females 0.5 0.5gram IM (single dose) Rectal gonorrhea in males 1 1 gram IM (single dose) Uncomplicated infections 2 1 gram every 12 hours IM or IV Moderate to severe infections 3-6 1-2 grams every 8 hours IM or IV Infections commonly needing
antibiotics in higher dosage (e.g., septicemia)
6-8 2 grams every 6-8 hours IV Life-threatening infections up to 12 2 grams every 4 hours IV
If C. trachomatis is a suspected pathogen, appropriate anti-chlamydial coverage should be added, because cefotaxime sodium has no activity against this organism. To prevent postoperative infection in contaminated or potentially contaminated surgery, the recommended dose is a single 1gram IM or IV administered 30 to 90 minutes prior to start of surgery